New research indicates that individuals who stop using popular GLP-1 drugs like Wegovy and Mounjaro may regain lost weight at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Findings released in a leading medical journal shows that while obese individuals frequently drop about a fifth of their body weight while on the medication, the mass comes back at an average rate of nearly a kilo each month after stopping.
"Users buying these treatments must be informed of the risk of fast rebound weight gain when the therapy ends," cautioned expert Dr. Susan Jebb.
That rate of regain suggests a reversion to starting mass within about a year and a half.
Analyzing Treatments
The research, which reviewed dozens of trials involving over 9,000 of patients, compared the results of GLP-1 agonists with conventional dieting.
Scientists point out that people who lose weight through dieting usually see a slower weight regain—perhaps 100 grams monthly—post-intervention.
Explaining the Quick Rebound
Experts suggest the mode of action of the drugs accounts for the accelerated weight return.
These medications copy a natural hormone called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the body to generate a reduced amount of its own natural hormone, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement leads to hunger is unsuppressed, making overeating far more likely."
A Chronic Issue?
Medical guidelines suggest the jabs for people with obesity-related health risks, alongside recommended lifestyle changes.
Professionals contend that, considering the likelihood of relapse, the treatment might need to be life-long.
This opinion is supported by drug manufacturers, who state that the findings "underscore the chronic nature of excess weight," akin to managing diseases like diabetes.
Patient Accounts
Users who have stopped the medication describe a intense resurgence of appetite.
"It felt as if a trigger flipping and you're instantly extremely hungry," described an individual.
The struggle is exacerbated if patients have not adopted permanent dietary or behavioural changes during treatment.
Growing Use
Survey data suggest that millions of adults in the UK have tried these injections in the past year, with interest being substantial.
- Adoption is greater among females than men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the drugs through private healthcare rather than public health services.
Ultimately, experts stress that while the jabs are powerful tools for weight loss, they are not a magic cure and maintained weight loss relies on ongoing behavioural support.
